Paul J Harrison Selected Research

Schizophrenia (Dementia Praecox)

9/2023	GRIN2A (NR2A): a gene contributing to glutamatergic involvement in schizophrenia.
1/2023	Glutamatergic dysfunction leads to a hyper-dopaminergic phenotype through deficits in short-term habituation: a mechanism for aberrant salience.
12/2022	CACNA1C (CaV1.2) and other L-type calcium channels in the pathophysiology and treatment of psychiatric disorders: Advances from functional genomics and pharmacoepidemiology.
11/2021	Deletion of AMPA receptor GluA1 subunit gene (Gria1) causes circadian rhythm disruption and aberrant responses to environmental cues.
3/2018	Neuregulin 1 Type I Overexpression Is Associated with Reduced NMDA Receptor-Mediated Synaptic Signaling in Hippocampal Interneurons Expressing PV or CCK.
1/2018	D-Amino Acid Oxidase Inhibition: A New Glutamate Twist for Clozapine Augmentation in Schizophrenia?
1/2018	Absent sleep EEG spindle activity in GluA1 (Gria1) knockout mice: relevance to neuropsychiatric disorders.
12/2017	A group II metabotropic glutamate receptor 3 (mGlu3, GRM3) isoform implicated in schizophrenia interacts with canonical mGlu3 and reduces ligand binding.
1/2017	The group II metabotropic glutamate receptor agonist LY354740 and the D2 receptor antagonist haloperidol reduce locomotor hyperactivity but fail to rescue spatial working memory in GluA1 knockout mice.
1/2017	Prevalence and clinical characteristics of serum neuronal cell surface antibodies in first-episode psychosis: a case-control study.

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Paul J Harrison Research Topics

Disease

49	Schizophrenia (Dementia Praecox) 09/2023 - 09/2002
16	Bipolar Disorder (Manic Depressive Psychosis) 12/2022 - 02/2004
11	Mental Disorders (Mental Disorder) 01/2023 - 01/2004
9	COVID-19 01/2024 - 01/2021
7	Psychotic Disorders (Schizoaffective Disorder) 01/2023 - 07/2006
4	Sleep Initiation and Maintenance Disorders (Insomnia) 01/2022 - 05/2015
4	Mood Disorders (Mood Disorder) 01/2019 - 10/2004
4	Paranoid Disorders (Paranoia) 10/2017 - 03/2015
3	Infections 01/2024 - 01/2022
3	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 11/2003
3	Neurodevelopmental Disorders 10/2017 - 09/2003
2	Epilepsy (Aura) 01/2022 - 11/2003
2	Sleep Wake Disorders 01/2022 - 01/2022
2	Dementia (Dementias) 01/2022 - 01/2021
2	Delirium 01/2021 - 01/2020
2	Glioma (Gliomas) 06/2010 - 06/2002
2	Starvation 06/2008 - 06/2000
2	Weight Gain 04/2005 - 04/2004
1	Nervous System Trauma 01/2024
1	Hyperprolactinemia 10/2023
1	Venous Thromboembolism 01/2022
1	Treatment-Resistant Depressive Disorder 01/2022
1	Respiratory Insufficiency (Respiratory Failure) 01/2022
1	Alopecia (Baldness) 01/2022
1	Seizures (Absence Seizure) 01/2022
1	Post-Acute COVID-19 Syndrome 01/2022
1	Venous Thrombosis (Deep-Vein Thrombosis) 09/2021
1	Human Influenza (Influenza) 09/2021
1	Inflammation (Inflammations) 01/2021
1	Stroke (Strokes) 01/2021
1	Brain Diseases (Brain Disorder) 01/2021
1	Cerebrovascular Disorders (Cerebrovascular Occlusion) 01/2021
1	Encephalitis (Encephalitis, Rasmussen) 01/2019

Drug/Important Bio-Agent (IBA)

12	Messenger RNA (mRNA)IBA 10/2014 - 09/2002
11	Protein Isoforms (Isoforms)IBA 12/2022 - 04/2005
10	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 09/2023 - 09/2003
7	Proteins (Proteins, Gene)FDA Link 10/2017 - 04/2005
6	Glutamic Acid (Glutamate)FDA Link 09/2023 - 06/2002
6	AntibodiesIBA 01/2020 - 11/2016
6	Neuregulin-1 (Neuregulin 1)IBA 03/2018 - 04/2006
5	Dopamine (Intropin)FDA LinkGeneric 10/2023 - 09/2013
5	Serotonin (5 Hydroxytryptamine)IBA 01/2021 - 06/2002
5	metabotropic glutamate receptor 3 (mGluR3)IBA 12/2017 - 10/2008
4	Calcium Channels (Calcium Channel)IBA 12/2022 - 01/2016
4	LithiumIBA 01/2022 - 01/2016
4	D-Amino-Acid Oxidase (D-Amino Acid Dehydrogenase)IBA 01/2018 - 09/2007
4	Antipsychotic Agents (Antipsychotics)IBA 01/2017 - 09/2002
4	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA 01/2015 - 02/2008
3	CalciumIBA 12/2022 - 06/2002
3	Antihypertensive Agents (Antihypertensives)IBA 01/2021 - 01/2020
3	Serine (L-Serine)FDA Link 10/2014 - 09/2007
3	Catechol O-Methyltransferase (Methyltransferase, Catechol)IBA 12/2008 - 02/2004
2	Biomarkers (Surrogate Marker)IBA 10/2023 - 01/2021
2	N-Methylaspartate (NMDA)IBA 09/2023 - 10/2014
2	L-Type Calcium Channels (Dihydropyridine Receptor)IBA 12/2022 - 02/2019
2	Gabapentin (Neurontin)FDA LinkGeneric 01/2022 - 01/2017
2	Valproic Acid (Depakote)FDA LinkGeneric 01/2022 - 01/2022
2	Pregabalin (Lyrica)FDA Link 01/2022 - 01/2017
2	AMPA Receptors (AMPA Receptor)IBA 11/2021 - 01/2018
2	AcidsIBA 11/2021 - 01/2018
2	DiureticsIBA 01/2021 - 01/2020
2	Calcium Channel Blockers (Blockers, Calcium Channel)IBA 01/2020 - 01/2020
2	Dihydrotachysterol (AT 10)IBA 10/2017 - 05/2015
2	Glutamate Receptors (Glutamate Receptor)IBA 01/2017 - 11/2003
2	Complement System Proteins (Complement)IBA 01/2017 - 03/2012
2	Dronabinol (THC)FDA LinkGeneric 11/2015 - 03/2015
2	NeuregulinsIBA 07/2012 - 02/2003
2	metabotropic glutamate receptor 2IBA 12/2011 - 11/2008
2	EnzymesIBA 01/2011 - 09/2007
2	netrin-G1IBA 06/2010 - 03/2008
2	serine racemaseIBA 06/2010 - 09/2007
2	CalcineurinIBA 12/2005 - 04/2005
2	5-HT2C Serotonin ReceptorIBA 04/2005 - 04/2004
1	tau Proteins (tau Protein)IBA 01/2024
1	Glial Fibrillary Acidic ProteinIBA 01/2024
1	Cholinergic Agents (Cholinergics)IBA 10/2023
1	Adrenergic Agents (Adrenergic Drugs)IBA 10/2023
1	Antidepressive Agents (Antidepressants)IBA 01/2022
1	Levetiracetam (Keppra)FDA LinkGeneric 01/2022
1	Protein Kinase InhibitorsIBA 01/2022
1	Influenza Vaccines (Influenza Vaccine)FDA Link 01/2022
1	Pramipexole (Mirapex)FDA LinkGeneric 01/2022
1	COVID-19 VaccinesIBA 01/2022
1	Amlodipine (Norvasc)FDA LinkGeneric 01/2022
1	Oxygen (Dioxygen)IBA 01/2022
1	Antiviral Agents (Antivirals)IBA 01/2022
1	Phenytoin (Dilantin)FDA LinkGeneric 01/2022
1	Angiotensin Receptor AntagonistsIBA 01/2022
1	VaccinesIBA 09/2021
1	mRNA VaccinesIBA 09/2021
1	Ad26COVS1IBA 09/2021
1	ChAdOx1 nCoV-19IBA 09/2021
1	Clostridium perfringens epsilon-toxinIBA 01/2021
1	Thrombin FDA Link 01/2021
1	antineoplaston A10 (A 10)IBA 01/2019
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 03/2018

Therapy/Procedure

6	Therapeutics 01/2021 - 01/2011
1	Critical Care (Surgical Intensive Care) 01/2023
1	Drug Therapy (Chemotherapy) 01/2021
1	Immunotherapy 01/2019